01
BMP15
No data
- Entity Type
- Diseases
- Relation Groups
- 1
- Relation Preview
- 8
Basic Information
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Core Information
- Disease Name
- Ovarian Failure, Premature
- Standard Disease Name
- ovarian failure, premature
- MeSH Tree
- No data
- ICD-10
- E28.3
Identifiers
- DO ID
- No data
- MeSH ID
- D016649
- OMIM ID
- MTHU019319|MTHU031802|311360|MTHU037282|MTHU050435
- UMLS ID
- C0085215
- HPO ID
- No data
Description and Extensions
- Description
- NCI2016_NICHD_1602D:Absent or premature cessation of ovarian function due to an issue originating within the ovaries.|NCI2016_NCI-GLOSS_1602D:A condition in which the ovaries stop working and menstrual periods stop before age 40. Natural menopause usually occurs around age 50. A woman is said to be in menopause when she hasn't had a period for 12 months in a row. Symptoms of menopause include hot flashes, mood swings, night sweats, vaginal dryness, trouble concentrating, and infertility. Primary ovarian insufficiency can be caused by some cancer treatments, surgery to remove the ovaries, and certain diseases or genetic conditions. Also called early menopause, premature menopause, and premature ovarian failure.|NCI2016_02D:Absent or premature cessation of ovarian function due to a pathologic process originating within the ovaries.(NICHD)|MSH2017_2016_08_12:Cessation of ovarian function after MENARCHE but before the age of 40, without or with OVARIAN FOLLICLE depletion. It is characterized by the presence of OLIGOMENORRHEA or AMENORRHEA, elevated GONADOTROPINS, and low ESTRADIOL levels. It is a state of female HYPERGONADOTROPIC HYPOGONADISM. Etiologies include genetic defects, autoimmune processes, chemotherapy, radiation, and infections.|MEDLINEPLUS_20151021:<p>Premature ovarian failure (POF) is when a woman's ovaries stop working before she is 40.</p> <p>POF is different from premature <a href='https://www.nlm.nih.gov/medlineplus/menopause.html'>menopause</a>. With premature menopause, your periods stop before age 40. You can no longer get pregnant. The cause can be natural or it can be a disease, surgery, chemotherapy, or radiation. With POF, some women still have occasional periods. They may even get pregnant. In most cases of POF, the cause is unknown.</p> <p>Missed periods are usually the first sign of POF. Later symptoms may be similar to those of natural menopause:</p> <ul> <li>Hot flashes</li> <li>Night sweats</li> <li>Irritability</li> <li>Poor concentration</li> <li>Decreased sex drive</li> <li>Pain during sex</li> <li>Vaginal dryness</li> </ul> <p>Doctors diagnose POF by doing a physical exam and lab and imaging tests.</p> <p>Most women with POF cannot get pregnant naturally. Fertility treatments help a few women; others use donor eggs to have children. There is no treatment that will restore normal ovarian function. However, many health care providers suggest taking hormones until age 50. </p> <p >NIH: National Institute of Child Health and Human Development</p>|HPO2016_07_04:Malfunctioning of the ovaries such that a girl never begins menstruation. [HPO:probinson]
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