Diseases

Necrosis

necrosis

Entity Type: Diseases
Relation Groups: 4
Relation Preview: 32

Basic Information

Grouped by core information, identifiers, and descriptions.

Current candidates are inferred from disease-target-ingredient-herb paths and do not represent a formal recommendation ranking.

Core Information

Disease Name: Necrosis
Standard Disease Name: necrosis
MeSH Tree: No data
ICD-10: No data

Identifiers

DO ID: No data
MeSH ID: D009336
OMIM ID: MTHU039302|MTHU002552
UMLS ID: C0027540
HPO ID: No data

Description and Extensions

Description: NCI2016_NCI-GLOSS_1602D:Refers to the death of tissues.|NCI2016_CDISC_1602D:Death of a group of cells in an organ or tissue. (INHAND)|NCI2016_02D:Relating to or affected by necrosis.|NCI2016_02D:A cell death process that is morphologically characterized by a gain in cell volume (oncosis), swelling of organelles, plasma membrane rupture and subsequent loss of intracellular contents.|MSH2017_2016_08_12:The pathological process occurring in cells that are dying from irreparable injuries. It is caused by the progressive, uncontrolled action of degradative ENZYMES, leading to MITOCHONDRIAL SWELLING, nuclear flocculation, and cell lysis. It is distinct it from APOPTOSIS, which is a normal, regulated cellular process.|GO2016_05_01:OBSOLETE. The processes that cause necrosis, the death of tissues, in another organism. [GOC:ma]|GO2016_05_01:OBSOLETE. A permanent cessation of all vital functions of a tissue. [GOC:dph, GOC:mtg_apoptosis]|GO2016_05_01:A type of cell death that is morphologically characterized by an increasingly translucent cytoplasm, swelling of organelles, minor ultrastructural modifications of the nucleus (specifically, dilatation of the nuclear membrane and condensation of chromatin into small, irregular, circumscribed patches) and increased cell volume (oncosis), culminating in the disruption of the plasma membrane and subsequent loss of intracellular contents. Necrotic cells do not fragment into discrete corpses as their apoptotic counterparts do. Moreover, their nuclei remain intact and can aggregate and accumulate in necrotic tissues. [GOC:mtg_apoptosis, PMID:18846107, PMID:20823910]|CSP2006:sum of the morphological changes indicative of cell death and caused by the progressive degradation action of enzymes; may affect groups of cells or part of a structure or an organ.

Direct relations and traceable candidates grouped by relation type.