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CECR2
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- Entity Type
- Diseases
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Basic Information
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Core Information
- Disease Name
- Neural Tube Defects
- Standard Disease Name
- neural tube defects
- MeSH Tree
- No data
- ICD-10
- No data
Identifiers
- DO ID
- No data
- MeSH ID
- D009436
- OMIM ID
- MTHU048953
- UMLS ID
- C0027794
- HPO ID
- No data
Description and Extensions
- Description
- NCI2016_02D:A congenital defect characterized by failure of the neural tube to close completely; this results in the presence of openings in the brain or spinal cord. Examples of neural tube defects include encephalocele and spina bifida.|MSH2017_2016_08_12:Congenital malformations of the central nervous system and adjacent structures related to defective neural tube closure during the first trimester of pregnancy generally occurring between days 18-29 of gestation. Ectodermal and mesodermal malformations (mainly involving the skull and vertebrae) may occur as a result of defects of neural tube closure. (From Joynt, Clinical Neurology, 1992, Ch55, pp31-41)|MEDLINEPLUS_20151021:<p>Neural tube defects are <a href='https://www.nlm.nih.gov/medlineplus/birthdefects.html'>birth defects</a> of the brain, spine, or spinal cord. They happen in the first month of pregnancy, often before a woman even knows that she is pregnant. The two most common neural tube defects are <a href='https://www.nlm.nih.gov/medlineplus/spinabifida.html'>spina bifida</a> and anencephaly. In spina bifida, the fetal spinal column doesn't close completely. There is usually nerve damage that causes at least some paralysis of the legs. In anencephaly, most of the brain and skull do not develop. Babies with anencephaly are usually either stillborn or die shortly after birth. Another type of defect, <a href='https://www.nlm.nih.gov/medlineplus/chiarimalformation.html'>Chiari malformation</a>, causes the brain tissue to extend into the spinal canal.</p> <p>The exact causes of neural tube defects aren't known. You're at greater risk of having an infant with a neural tube defect if you</p> <ul> <li>Are obese</li> <li>Have poorly controlled diabetes</li> <li>Take certain antiseizure medicines</li> </ul> <p>Getting enough <a href='https://www.nlm.nih.gov/medlineplus/folicacid.html'>folic acid</a>, a type of B vitamin, before and during pregnancy prevents most neural tube defects.</p> <p>Neural tube defects are usually diagnosed before the infant is born, through lab or imaging tests. There is no cure for neural tube defects. The nerve damage and loss of function that are present at birth are usually permanent. However, a variety of treatments can sometimes prevent further damage and help with complications.</p> <p >NIH: National Institute of Child Health and Human Development</p>|HPO2016_07_04:A neural tube defect arises when the neural tube, the embryonic precursor of the brain and spinal cord, fails to close during neurulation. The cranial region (anencephaly) or the low spine (open spina bifida; myelomeningocele) are most commonly affected although, in the severe NTD craniorachischisis, almost the entire neural tube remains open, from midbrain to low spine. [HPO:probinson, PMID:19808787]|HPO2016_07_04:A heterogeneous group of congenital spinal anomalies that result from defective closure of the neural tube early in fetal life. [HPO:probinson]
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