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Core Information
Disease Name
Landau-Kleffner Syndrome
Standard Disease Name
landau-kleffner syndrome
MeSH Tree
No data
ICD-10
G40.8
Identifiers
DO ID
No data
MeSH ID
D018887
OMIM ID
245570
UMLS ID
C0282512
HPO ID
No data
Description and Extensions
Description
NCI2016_02D:A rare childhood syndrome characterized by the progressive or sudden inability to understand and use spoken language (aphasia) and paroxysmal electrical brain waves. Patients develop epileptic seizures and behavioral changes.|MSH2017_2016_08_12:A syndrome characterized by the onset of isolated language dysfunction in otherwise normal children (age of onset 4-7 years) and epileptiform discharges on ELECTROENCEPHALOGRAPHY. Seizures, including atypical absence (EPILEPSY, ABSENCE), complex partial (EPILEPSY, COMPLEX PARTIAL), and other types may occur. The electroencephalographic abnormalities and seizures tend to resolve by puberty. The language disorder may also resolve although some individuals are left with severe language dysfunction, including APHASIA and auditory AGNOSIA. (From Menkes, Textbook of Child Neurology, 5th ed, pp749-50; J Child Neurol 1997 Nov;12(8):489-495)
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