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Diseases

Barrett Esophagus

barrett esophagus

Entity Type
Diseases
Relation Groups
2
Relation Preview
16

Basic Information

Grouped by core information, identifiers, and descriptions.

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Core Information

Disease Name
Barrett Esophagus
Standard Disease Name
barrett esophagus
MeSH Tree
No data
ICD-10
No data

Identifiers

DO ID
No data
MeSH ID
No data
OMIM ID
614266
UMLS ID
C0004763|C0004763|C0279628
HPO ID
No data

Description and Extensions

Description
NCI2016_NCI-GLOSS_1602D:A condition in which the cells lining the lower part of the esophagus have changed or been replaced with abnormal cells that could lead to cancer of the esophagus. The backing up of stomach contents (reflux) may irritate the esophagus and, over time, cause Barrett's esophagus.|NCI2016_02D:Esophageal lesion lined with columnar metaplastic epithelium which is flat or villiform. Barrett epithelium is characterized by two different types of cells: goblet cells and columnar cells. The symptomatology of Barrett esophagus is that of gastro-esophageal reflux. It is the precursor of most esophageal adenocarcinomas. (WHO)|MSH2017_2016_08_12:A condition with damage to the lining of the lower ESOPHAGUS resulting from chronic acid reflux (ESOPHAGITIS, REFLUX). Through the process of metaplasia, the squamous cells are replaced by a columnar epithelium with cells resembling those of the INTESTINE or the salmon-pink mucosa of the STOMACH. Barrett's columnar epithelium is a marker for severe reflux and precursor to ADENOCARCINOMA of the esophagus.|HPO2016_07_04:An abnormal change (metaplasia) in the cells of the inferior portion of the esophagus. The normal squamous epithelium lining of the esophagus is replaced by metaplastic columnar epithelium. Columnar epithelium refers to a cell type that is typically found in more distal parts of the gastrointestinal system. [HPO:sdoelken]|CSP2006:syndrome including peptic ulcer of the lower esophagus, often with stricture, due to the presence of columnar lined epithelium, which may contain functional mucous cells, parietal cells, or chief cells in the esophagus instead of normal squamous cell epithelium; sometimes pre-malignant, followed by esophageal adenocarcinoma.
Related

Direct relations and traceable candidates grouped by relation type.

Related Targets

target disease8 Targets
08
SOCS1
suppressor of cytokine signaling 1
suppressor of cytokine signaling 1