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ADAMTS13
No data
Diseases
Immune Thrombocytopenic Purpura
immune thrombocytopenic purpura
- Entity Type
- Diseases
- Relation Groups
- 1
- Relation Preview
- 8
Basic Information
Grouped by core information, identifiers, and descriptions.
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Core Information
- Disease Name
- Immune Thrombocytopenic Purpura
- Standard Disease Name
- immune thrombocytopenic purpura
- MeSH Tree
- No data
- ICD-10
- D80.3
Identifiers
- DO ID
- No data
- MeSH ID
- D017099
- OMIM ID
- MTHU012163|MTHU006900
- UMLS ID
- C0162539
- HPO ID
- No data
Description and Extensions
- Description
- NCI2016_02D:A classification of dysgammaglobulinemias characterized by low or undetectable serum levels of one of the four immunoglobulin class G (IgG) subclasses. Selective IgG1 deficiency is rare and primarily decreases the immune response to bacterial protein antigens. Selective IgG2 deficiency is the most common subclass deficiency among children and primarily leads to an inadequate response to bacterial polysaccharide antigens. Selective IgG3 deficiency is the most common subclass deficiency among adults and also primarily lowers the response to bacterial proteins. Selective IgG4 deficiency may be a clinically insignificant developmental variant, as IgG4 is a subclass that is virtually undetectable until the end of the first decade of life. Low levels of any IgG subclass will reduce the immune system's effectiveness and thus the clinical presentation of these diseases is usually recurrent infection, particularly by encapsulated bacteria.|NCI2016_02D:A broad classification of dysgammaglobulinemias characterized by low or undetectable serum levels of immunoglobulin class G (IgG). Deficiencies of IgG present variably according to subclass. IgG deficiencies are typically relative among subclasses and not absolute. Thus even with a given selective IgG subclass deficiency, total IgG levels may still fall within normal range. The clinical course and prognosis is dependent upon the severity of the deficiency and associated morbidity.|MSH2017_2016_08_12:A dysgammaglobulinemia characterized by a deficiency of IMMUNOGLOBULIN G.|HPO2016_07_04:An abnormally decreased level of immunoglobulin IgG in blood. [HPO:probinson]
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Related Targets
target disease8 Targets