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- Entity Type
- Diseases
- Relation Groups
- 1
- Relation Preview
- 8
Basic Information
Grouped by core information, identifiers, and descriptions.
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Core Information
- Disease Name
- Carcinogenesis
- Standard Disease Name
- carcinogenesis
- MeSH Tree
- No data
- ICD-10
- A81.2
Identifiers
- DO ID
- No data
- MeSH ID
- D007968
- OMIM ID
- No data
- UMLS ID
- C0023524
- HPO ID
- No data
Description and Extensions
- Description
- NCI2016_NICHD_1602D:A demyelinating central nervous system disease caused by reactivation of the polyomavirus JC, which results in a lytic infection of oligodendrocytes.|NCI2016_02D:A progressive demyelination within the central nervous system associated with reactivation of a latent JC virus infection.|MSH2017_2016_08_12:An opportunistic viral infection of the central nervous system associated with conditions that impair cell-mediated immunity (e.g., ACQUIRED IMMUNODEFICIENCY SYNDROME and other IMMUNOLOGIC DEFICIENCY SYNDROMES; HEMATOLOGIC NEOPLASMS; IMMUNOSUPPRESSION; and COLLAGEN DISEASES). The causative organism is JC Polyomavirus (JC VIRUS) which primarily affects oligodendrocytes, resulting in multiple areas of demyelination. Clinical manifestations include DEMENTIA; ATAXIA; visual disturbances; and other focal neurologic deficits, generally progressing to a vegetative state within 6 months. (From Joynt, Clinical Neurology, 1996, Ch26, pp36-7)|CSP2006:demyelination in various part of the central nervous system, usually secondary to neoplastic disease; JC virus has been recovered from brain tissue.