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Herb Integrative Database
Traditional Medicine Data Platform
Diseases

Necrosis

necrosis

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Entity Type
Diseases
Relation Groups
2
Relation Preview
16

Basic Information

Grouped by core information, identifiers, and descriptions.

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Core Information

Disease Name
Necrosis
Standard Disease Name
necrosis
MeSH Tree
No data
ICD-10
No data

Identifiers

DO ID
No data
MeSH ID
D009336
OMIM ID
MTHU039302|MTHU002552
UMLS ID
C0027540
HPO ID
No data

Description and Extensions

Description
NCI2016_NCI-GLOSS_1602D:Refers to the death of tissues.|NCI2016_CDISC_1602D:Death of a group of cells in an organ or tissue. (INHAND)|NCI2016_02D:Relating to or affected by necrosis.|NCI2016_02D:A cell death process that is morphologically characterized by a gain in cell volume (oncosis), swelling of organelles, plasma membrane rupture and subsequent loss of intracellular contents.|MSH2017_2016_08_12:The pathological process occurring in cells that are dying from irreparable injuries. It is caused by the progressive, uncontrolled action of degradative ENZYMES, leading to MITOCHONDRIAL SWELLING, nuclear flocculation, and cell lysis. It is distinct it from APOPTOSIS, which is a normal, regulated cellular process.|GO2016_05_01:OBSOLETE. The processes that cause necrosis, the death of tissues, in another organism. [GOC:ma]|GO2016_05_01:OBSOLETE. A permanent cessation of all vital functions of a tissue. [GOC:dph, GOC:mtg_apoptosis]|GO2016_05_01:A type of cell death that is morphologically characterized by an increasingly translucent cytoplasm, swelling of organelles, minor ultrastructural modifications of the nucleus (specifically, dilatation of the nuclear membrane and condensation of chromatin into small, irregular, circumscribed patches) and increased cell volume (oncosis), culminating in the disruption of the plasma membrane and subsequent loss of intracellular contents. Necrotic cells do not fragment into discrete corpses as their apoptotic counterparts do. Moreover, their nuclei remain intact and can aggregate and accumulate in necrotic tissues. [GOC:mtg_apoptosis, PMID:18846107, PMID:20823910]|CSP2006:sum of the morphological changes indicative of cell death and caused by the progressive degradation action of enzymes; may affect groups of cells or part of a structure or an organ.
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